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UK becomes 1st country to approve gene therapy treatment for sickle cell, thalassemia

Published Wed, 05 Mar 2025 02:26:52 GMT

LONDON (AP) — Britain’s medicines regulator has authorized the world’s first gene therapy treatment for sickle cell disease, in a move that could offer relief to thousands of people with the crippling disease in the U.K.In a statement on Thursday, the Medicines and Healthcare Regulatory Agency said it approved Casgevy, the first medicine licensed using the gene editing tool CRISPR, which won its makers a Nobel prize in 2020. The agency approved the treatment for patients with sickle cell disease and thalassemia who are 12 years old and over. Casgevy is made by Vertex Pharmaceuticals (Europe) Ltd. and CRISPR Therapeutics. To date, bone marrow transplants, an extremely arduous procedure that come with very unpleasant side effects, have been the only long-lasting treatment. “The future of life changing cures resides in CRISPR based (gene-editing) technology,” said Dr. Helen O’Neill of University College London. “The use of the word ‘cure’ in relation to sickle cell di...

Nice: Q3 Earnings Snapshot

Published Wed, 05 Mar 2025 02:26:52 GMT

RA`ANANA, Israel (AP) — RA`ANANA, Israel (AP) — Nice Ltd. (NICE) on Thursday reported third-quarter profit of $92.4 million.The Ra`Anana, Israel-based company said it had net income of $1.39 per share. Earnings, adjusted for stock option expense and amortization costs, came to $2.27 per share.The results exceeded Wall Street expectations. The average estimate of eight analysts surveyed by Zacks Investment Research was for earnings of $2.15 per share.The software company posted revenue of $601.3 million in the period, also beating Street forecasts. Six analysts surveyed by Zacks expected $594.6 million.Nice expects full-year earnings in the range of $8.58 to $8.78 per share, with revenue in the range of $2.36 billion to $2.38 billion._____This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on NICE at https://www.zacks.com/ap/NICESource

Violence erupts at protest outside DNC in Southeast calling for cease-fire in Gaza

Published Wed, 05 Mar 2025 02:26:52 GMT

Violence broke out at a protest outside the Democratic National Committee on Wednesday night with demonstrators calling for a cease-fire in Gaza.The U.S. Capitol Police said six of their officers were hurt and their injuries ranged from minor cuts to being pepper sprayed to being punched. The department said one person was arrested in connection with assaulting an officer.Just after 8:30 p.m., Capitol Police said their officers were working to keep back about 150 people who were illegally and violently protesting in the area of Ivy and Canal streets in Southeast. The protest was organized by a coalition of groups, including If Not Now and Jewish Voice for Peace Action, that have spearheaded other demonstrations including one where 300 people were arrested on Capitol Hill in October.Many Democratic representatives, including House Minority Leader Hakeem Jeffries, were inside the building for a campaign reception when it was interrupted by chanting outside.Video posted to X, formerly ...

¿Qué estará abierto y cerrado en Thanksgiving? Aquí la lista completa

Published Wed, 05 Mar 2025 02:26:52 GMT

Si te preguntas qué compras de último minuto puedes hacer el mismo día de Thanksgiving, presta mucha atención a los horarios de este año. Muchas tiendas cerrarán sus puertas durante Acción de Gracias, siguiendo una tendencia que comenzó durante la pandemia del COVID-19.En años pasados, los minoristas se encontraron con un frenesí de compradores que buscaban obtener las mejores ofertas durante la temporada navideña, incluso si eso significaba abandonar temprano la cena familiar para llegar al centro comercial.Este año, las principales tiendas como Kohl’s, Target y Walmart permanecerán cerradas mientras los estadounidenses se deleitan en la mesa en Acción de Gracias. CNBC: Google Maps te aconseja sobre cuándo realizar tus viajes de Thanksgiving ¿Estás a cargo del pavo este Thanksgiving? Aquí tienes dos formas de descongelarlo Estos son los supermercados y las tiendas que estarán abiertas y cerradas el 23 de noviembre de 2023....

Denver weather: Mild, breezy with morning mountain snow

Published Wed, 05 Mar 2025 02:26:52 GMT

DENVER (KDVR) — Thursday's Denver weather forecast starts with light snow showers in the mountains, partly cloudy skies in the city and light evening showers over the plains. Weather today: Mild with sun, cloudsLight snow showers will push into the mountains Thursday morning and will wrap up by midday, with some snow lingering in the northern mountains. Evacuations lifted after home explodes in Wellington neighborhood Totals will only amount to a few inches with brisk winds. Pinpoint Weather: Snowfall outlook on Nov. 16 Denver will see a mix of sun and clouds with breezy afternoon winds. Highs will be in the upper 60s. The northeastern corner of the state could see some light rain showers in the evening.Pinpoint Weather: Daily forecast on Nov. 16 Weather tonight: Partly cloudyThe breezy wind will slow overnight with decreasing clouds. Low temperatures Thursday night will dip into the low 30s, bringing some freezing conditions back to the metro.Pinpoint Weather: Overnight forecast...

Denver metro among worst cities for package theft in 2023

Published Wed, 05 Mar 2025 02:26:52 GMT

(NewsNation) — The Seattle metro area is the worst region for package theft in the country as porch pirates continue to plague communities across the U.S., according to a new report. That ranking comes from SafeWise's 6th Annual Package Theft Report, which found thieves stole an estimated 119 million packages nationwide over the past year — a 5% increase from the year prior. After coming in second in 2022, the Seattle-Tacoma-Bellevue area now tops the list of U.S. metros for worst package theft. The Emerald City is followed by Memphis, San Diego-Chula Vista-Carlsbad, California; Birmingham-Hoover, Alabama; and Denver-Aurora-Lakewood, Colorado. Why the holiday season sees more ‘porch pirates’ SafeWise, an online guide to safety and security products, determines its rankings using a combination of FBI larceny-theft statistics and Google Trends data.The new report comes during a holiday shopping season where U.S. shoppers are expected to spend more than $270 billion online. It...

Fallen tree blocks lanes on eastbound MacArthur Causeway causing traffic delays

Published Wed, 05 Mar 2025 02:26:52 GMT

Authorities have blocked off the MacArthur Causeway after a tree fell onto the road, Thursday. Live video footage showed two lanes blocked as the branches of a tree obstructed the roadway. The congestion was evident just before Bridge Road as officers blocked off the road to keep drivers safe. Drivers are urged to exercise caution and seek alternative routes as crews work to clear the roadway.

Family displaced after abandoned structure collapses in Miami

Published Wed, 05 Mar 2025 02:26:52 GMT

Miami Fire Rescue responded to a collapsed building in the area that displaced a family living nearby, Thursday morning. The abandoned structure, located on Northwest 18th Avenue and Third Street, fell overnight onto an adjacent property, piercing the roof. A family of three, along with their animals, living in the home next door are currently displaced as a result of the collapse. Emergency crews are on the scene assessing the situation. Please check back on WSVN.com and 7News for more details on this developing story.

South Florida braces for ongoing rain rounds; advisories and closures remain in effect

Published Wed, 05 Mar 2025 02:26:52 GMT

MIAMI-DADE/BROWARD COUNTIES, Fla. (WSVN) — South Florida faced a relentless storm, unleashing heavy rain, thunderstorms, and whipping winds throughout Wednesday. The aftermath reveals a region grappling with the impact of widespread flooding and record-breaking gusts. The widespread flooding has left many cars stranded across Miami-Dade County and Broward County. The aftermath of Wednesday’s heavy rainfall has resulted in road closures and has led Broward County Public Schools and Broward College to cancel classes on Thursday.A sinkhole opened at the intersection of Northwest 186th Street and 68th Avenue, leaving two cars submerged. Officials have not yet determined what led to the sinkhole, but the rain could be a factor.Miami Beach experienced gusts reaching 74 miles per hour, indicative of the intensity of the storm. Rainfall totals across South Florida are substantial, with a notable peak of 9.57 inches in Coral Gables from Tuesday morning through Thursday. In Aven...

Spain’s parliament confirms Pedro Sánchez as prime minister

Published Wed, 05 Mar 2025 02:26:52 GMT

Pedro Sánchez won the backing of a majority of lawmakers in Spain’s parliament to form a new government on Thursday, bringing four months of political paralysis in Madrid to an end.The 51-year-old premier prevailed in a vote in Spain’s hyper-fractured, 350-seat parliament, obtaining yea votes from every left-wing and separatist group. In all, 179 lawmakers backed Sánchez.All seven lawmakers belonging to the Catalan separatist Junts party, which had the power to either make Sánchez prime minister or force Spain to hold new elections, voted in his favor. So, too, did the sole representative of the Canarian Coalition, who last month also voted in favor of center-right Popular Party leader Alberto Núñez Feijóo’s failed bid to form a government.As expected, the 171 lawmakers belonging to Feijóo’s party and the far-right Vox group, as well as the conservative Navarrese People’s Union, voted against the socialist candidate.Sánchez’s win in parliament conc...